Crush Goals With Creatine Monohydrate-

Creatine Monohydrate is a supplement staple for any serious bodybuilder or athlete that is looking to make increases in muscle mass and high-intensity performance. Creatine works by producing higher levels of ATP, which may elevate short-burst energy levels for many athletic activities including powerlifting and sprinting.

Creatine is the most studied and scientifically proven performance supplement on the market. For a no nonsense and affordable supplement that may assist in increasing energy, building lean muscle and aiding in explosive strength, Creatine Monohydrate is a clear choice for both gym and field.

Read below for more information on how Creatine works with the body to increase short-burst energy performance and overall strength.

Creatine (CR) is a naturally occurring substance, produced in our bodies in the liver from the amino acids L-Arginine, L-Glycine and L-Methionine(1). Daily turnover of creatine occurs at a rate of ~2g/day via non-enzymatic, irreversible degradation of creatine and creatine phosphate to creatinine(2). Creatinine freely diffuses out of the cell and is easily filtered by the healthy kidney(3). This loss is normally replaced by endogenous CR synthesis, as well as exogenous (dietary) sources of creatine such as meat(4). However, vegetarians typically have lower levels of creatine in serum and muscle(5), and experience a greater elevation in muscle CR following dietary supplementation(6).

Due in part to its relatively large mass, over 95% of the body’s store of creatine is found in skeletal muscle (~120g in a 70kg male(1)), where it participates in energetic processes to restore ATP and shuttle high energy phosphate in the form of CR phosphate from the mitochondria to the myofibrillar cross-bridges to generate muscular contractile force(7).

Because CR is a charged molecule(2) it must normally be transported across cell membranes by a CR transport protein, including that of the gut (for oral absorption) and skeletal muscle (for uptake into the cell)(8-11). Following a period of CR loading, all of a 5g daily dose of CR monohydrate is recoverable in the urine as CR or its degradative by-product creatinine(12), suggesting that in most individuals, absorption of creatine monohydrate is complete, at least at these doses.

However, anecdotal reports of gastric distress(13) suggest that some individuals may have difficulty absorbing CR in the amounts provided by a CR supplement. To aid in trans-membrane movement, ethyl esterification (akin to the acetylation of salicylic acid to make aspirin, a.k.a. acetylsalycylic acid) of drugs or other substances is commonly employed to bypass normal means of uptake, enhance bioavailability and reduce side effects(14). Although scientific investigation of the pharmacokinetics CR ethyl ester (CEE) is lacking, anecdotal reports of increased body mass without gastric discomfort are consistent with the abrupt weight gain noted in numerous research studies of CR monohydrate supplementation(15-22), suggesting the CEE does indeed make its way to skeletal muscle.

The ergogenic and anabolic effects of CR have been under investigation for m ore than a decade, with widely inconsistent results(23). However, taken as a whole the large body of literature suggests that supplemental CR can have ergogenic effects, especially during brief duration, high intensity exercise (such as resistance exercise) and in individuals who have low muscle CR levels, such as vegetarians, and those with abnormalities of CR metabolism(21, 24, 25). Creatine may also have an anti-inflammatory action(26, 27), aid in nerve re-generation(28) have an anabolic or anti-catabolic effect on skeletal muscle(29-32), although the literature is not consistent in this regard(33, 34), and/or prevent performance decrements during periods of high intensity training(35).

By aiding in muscular performance (training stimulus), affecting recovery via altering muscle protein metabolism or nerve function, CR would hypothetically enhance adaptation to exercise training, including the muscular growth adaptation to resistance training. The degree to which this occurs is likely dependent upon the degree to which supplemental CR increases muscle CR as well as body mass during the initial period of CR supplementation(36, 37).

Suggested Use

As a dietary supplement, take  1 serving (2g) 1-2 times daily.

Ingredients

Creatine Monohydrate.

Packaging

Packaged in heat-sealed foil pouches.

General Warnings

If you are currently pregnant or nursing, consult a physician prior to use. Keep out of the reach of children.

Allergen Warnings

This product is manufactured in a facility that also uses milk, soy, egg, peanut, Tree nut,  fish, crustaceans shellfish, and wheat, which may result in the presence of the allergen in this product. 

Volumetric Measures

Use the table below to approximate the gram equivalent weight for a given level measuring spoon (US Standard). Please note that accurate dosing should only be done with a recommended calibrated scale.

DISCLAIMER: The above description is provided for information only and does not constitute medical advice. Please consult your physician or the appropriately licensed professional before engaging in a program of exercise or nutritional supplementation. No information in this site has been reviewed by the FDA. No product is intended to treat, diagnose, or cure any disease.

References

1. Walker, J.B., Creatine: biosynthesis, regulation, and function. Adv Enzymol Relat Areas Mol Biol, 1979. 50: p. 177-242.

2. Wyss, M. and T. Wallimann, Creatine metabolism and the consequences of creatine depletion in muscle. Mol. Cell. Biochem., 1994. 133/134: p. 51-66.

3. Hoogwerf, B.J., et al., Urine C-peptide and creatinine (Jaffe method) excretion in healthy young adults on varied diets: sustained effects of varied carbohydrate, protein, and meat content. Am J Clin Nutr, 1986. 43(3): p. 350-60.

4. Harris, R.C., et al., The concentration of creatine in meat, offal and commercial dog food. Research in Veterinary Science, 1997. 62(1): p. 58-62.

5. Delanghe, J., et al., Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians. Clin Chem, 1989. 35(8): p. 1802-3.

6. Harris, R.C., et al., Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci.(Colch). 1992. 83: p. 367-374.

7. Bessman, S.P. and F. Savabi, The role of the phosphcreatine energy shuttle in exercise and muscle hypertrophy, in Proceedings of the 7th International Biochemistry of Exercise Conference held on June 1-4, 1988 in London, Ontario, Canada, A.W. Taylor, Editor. 1990, Human Kinetics Publishers: Champaign,IL. p. 167-178.