We set out to try to make the most potent over-the-counter products we could (with more coming down the pipeline). A-Bolic4 is a flavonoid-based (non-hormonal) muscle mass growth supplement and body re-partitioning agent. Non-hormonal, which means women can use it as well as men. And you can use it year-round, as again, it's non-hormonal.
The key ingredients in it are:
Apigenin
This is the compound it's based upon—the one ingredient responsible for the bulk of the effects. I know Turkesterone is listed on the label first, but that is because of FDA labeling rules, which state you must put the ingredient with the highest milligrams first on the label, and it goes downward from there. It's not a turkesterone-based product at all; that's just an addition we put in there besides the main core ingredient, Apigenin. A-bolic4 is a flavonoid product, and Apigenin is the main key ingredient in it. If you go to Google and search "Apigenin" and "muscle hypertrophy," you will see the main reasons this compound is in A-bolic4. Other things of note: the side effects of apigenin.
If you have low blood sugar and/or low blood pressure (which virtually every bodybuilder does not have), but just in case you are the rare person that does, apigenin will slightly lower blood sugar and blood pressure.
Most people want those effects, but a woman with already too low blood pressure might be reading this. Other things of note that are incredibly positive toward bodybuilders and fitness people are (please search in Google: "Apigenin inhibits pressure overload-induced cardiac hypertrophy") ...so right up every single large bodybuilder's alley there.
And as I have stated previously, search "Apigenin" and "cancer" to see a compound that attacks cancer cells like virtually no other.
Since the last time we sent out a newsletter about A-bolic4, two new studies have come to the forefront on Apigenin. A lot of people have seen this study [1], but this one [2] came out not too long ago, showing Apigenin stops the loss of muscle mass while aging [3] and shows Apigenin inhibits visceral fat mass of the abdomen.
Quercefit™
If you search "Emiq" and "muscle mass" in Google, you will see why we added enzymatically modified Quercetin into A-bolic4. Innophos came up with Emiq, which showed 17 times more bioavailability than regular quercetin, but Indena came out with Quercefit phytosome, and it's showing 20-24 times bioavailability of quercetin, so we tweaked the formula and went with the Quercefit™ version. To note, Quercefit can also slightly lower blood pressure.
Quercetin (Quercefit™) also has so many positive attributes, it's impossible to state them all— but for this particular situation concerning bodybuilders and fitness athletes, it's another compound that has incredible antioxidant attributes, shows inhibition of left ventricle hypertrophy, lowers blood pressure, and, of course, seems to potentiate muscle hypertrophy in large enough (absorption) dosages.
Take a look at these studies [4, 5, 6] for a deeper dive.
Turkesterone
So, we tried to make this the most anabolic compound we could create. We originally used Turkesterone as an addition to Apigenin (for protein synthesis reasons), but we are leaning toward tweaking this product and using full-spectrum Rhaponticum Carthamoides Extract in its place. Both have shown a great increase in systemic protein synthesis (up to 20- 25% increase in protein synthesis, thats a big deal!) and there are studies out there showing some of these protein synthesis raising compounds comparing with both Methylandrostenediol and Nerobol (steroids) in muscular growth.
Unlike steroids, which show toxicity and side effects, these compounds produced no side effects and increased muscular growth through protein synthesis enhancement.
We are leaning toward using a full-spectrum Rhaponticum carthamoides extract because some studies have shown a greater effect than using singular Ecdysterones alone (specifically, when you use Rhaponticum carthamoides with Rhodiola [7]). We are leaning toward tweaking Abolic in the near future because we like what that combo has to offer (both versions work for protein synthesis, but we are always on the ball, trying to improve things as much as we can). The only reason we have not changed out Turkesterone for Rhaponticum carthamoides extract so far is that the cost of the RCE is so much more than Turkesterone, and will make A-Bolic4's price rise significantly. We are waiting for a more feasible price point.
The Feedback
By now, we have feedback from many users of A-bolic4. The most repeated feedback is "you are never flat with it, you always have a 1/2 pumped look. It's almost impossible to look flat on it". Most people report it works best, usually at three caps morning and three caps night, if you are a smaller person under 210 lbs. And four caps morning and four caps night work best for anyone over 210.
Strength goes up in a steady, slow linear fashion. It does not work like steroids with an androgenic look and/or loading you full of water, so if that's the effect you want, it's best to pass on using it. It's not a drug that puts a false facade in the mirror—it's a compound that has been shown to put you in the best position to gain muscle mass over a period of time at an enhanced rate. "A steady long-term gain of muscle mass combined with a round (half pumped) look in musculature" is what the majority state.
This product has been FAR AND AWAY the most popular product bought and rebought over the years, easily 3-4X more sales on it than other products because it works great for 90% of the people who use it. Because it's non-hormonal, the percentage of women who buy it is really shocking—definitely a much larger ratio of women buying and re-buying it than virtually any other product we sell.
Our advice? Try it for yourself—shop A-Bolic4 and let the results speak for themselves.
Sources
1. Ono M, Yoshioka K, Itoh S. Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7. Sci Signal. 2017;10(499):eaam7710. doi:10.1126/scisignal.aam7710
2. Wang D, Yang Y, Zou X, Zhang J, Zheng Z, Wang Z. Antioxidant apigenin relieves age-related muscle atrophy by inhibiting oxidative stress and hyperactive mitophagy and apoptosis in skeletal muscle of mice. J Gerontol A Biol Sci Med Sci. 2020;75(11):2081–2088. doi:10.1093/gerona/glaa214
3. Bernaldo De Quiros, Y., Murray, K., Ludwig, K., Hutton, D., Seals, D., & Clayton, Z. (2023). Late-life oral supplementation with apigenin mitigates loss of skeletal muscle strength and mass, exercise intolerance, and frailty with aging in mice. Physiology. https://doi.org/physiol.2023.38.S1.5732888
4. Kohara, A., Machida, M., Setoguchi, Y. et al. Enzymatically modified isoquercitrin supplementation intensifies plantaris muscle fiber hypertrophy in functionally overloaded mice. J Int Soc Sports Nutr 14, 32 (2017). https://doi.org/10.1186/s12970-017-0190-y
5. NutraIngredients-USA. Modified quercetin facilitated muscle growth in young athletes: study finds. NutraIngredients-USA.com. 2019 Sept 16. Available from: https://www.nutraingredients-usa.com/Article/2019/09/16/Modified-quercetin-facilitated-muscle-growth-in-young-athletes-study-finds
6. Nishikawa, T., Takeda, R., Ueda, S., Igawa, K., Hirono, T., Okudaira, M., Mita, Y., Ohya, T., & Watanabe, K. (2025). Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: A randomized, double-blind, controlled trial. European Journal of Nutrition, 64(3), 117. https://doi.org/10.1007/s00394-025-03634-9
7. Fança-Berthon, P., Campredon, S., Py, G., Descossy, V., Van Ba, C. T., Philippe, A., Vernus, B., Bertrand-Gaday, C., Falcao, L., Bily, A., Roller, M., & Bonnieu, A. Rhaponticum carthamoides and Rhodiola rosea plant extracts: The right combination between both to get the optimal effect on muscle de novo protein synthesis and performance gain. The FASEB Journal, 31, 795.3. https://doi.org/10.1096/fasebj.31.1_supplement.795.3