Guggulsterones

Guggul is a unique compound that has been studied for its potential fat-burning effects for years.* Unlike many other fat burners, which work to raise the heart-rate or improve the body’s natural metabolism of certain fats and sugars, guggul extract (and its active ingredient, guggulsterones) is said to have an effect on the thyroid and hormone production related to metabolism.* Studies suggest that supplementing guggulsterones may have a positive effect on weight loss as a result.*

Guggul was first discovered and implemented into herbal medicine hundreds of years ago throughout its native land of India. As a natural herbal remedy, guggul sap from the myrrh tree was originally believed to help improve bile production and secretion, with the intended effect of lowering LDL cholesterol within the bloodstream1. Conflicting studies report that some of these claims may be inaccurate, and that guggulsterones may have little to no effect on cholesterol levels, whatsoever2,3. Continued research is warranted, in either case.

What has more people interested in this material is its potential as a mechanism for weight loss, acting through the thyroid to create a balance in the hormones triiodothyronine (T3) and thyroxine (T4) which govern metabolism4. In one commonly-cited study conducted at the Devi Ahilya University in India, researchers observed an increase in T3 concentration in animal subjects that were given an extract of the guggul plant, while T4 levels remained unchanged5. This suggests that a human application of this material may produce the same positive results in conjunction with proper diet and exercise, especially in individuals that suffer from thyroid imbalances like hypothyroidism.* A human trial that was conducted in 1995 with 58 overweight individuals did seem to confirm these findings, with an average weight loss of 4.95 pounds observed in individuals that were administered the material over the course of 30 days as compared to the control group6.

More importantly, these effects may be achieved without the stimulation of the central nervous system, as guggulsterones strictly act upon the thyroid.* This is especially important for individuals that may be suffering from heart conditions of any kind, or individuals who may be looking for additional aid in losing weight without the undesired jitters and crash that may often accompany the use of many CNS-stimulants.

Another positive effect that may result from the dietary supplementation of guggul extract is an improvement in overall skin health and appearance.* In a clinical trial, researchers for the Central Government Health Scheme in Jaipur observed a notable decrease in cases of skin inflammation and acne in the patients that were administered gugulipids (68%) as compared to a reduction of 65.2% in the group that was administered the standard tetracycline7. Furthermore, recurring bouts of skin inflammation occurred in four subjects that had been administered tetracycline, as opposed to the two subjects who received gugulipid treatment in the 3-month period following the exam7. Additional research may be required in order to determine if synthetically-derived guggulsterones could possess the same anti-inflammatory response as the native gugulipids found in the gum or plant extract.*

Guggul Extract 20mg Capsules (90 Capsules)

True Nutrition offers a natural version of guggulsterones that has been standardized to 20% pure guggulsterones. This includes an average 51.5% of Z Guggulsterones, and 48.4% E Guggulsterones. One standard serving (1 capsule) contains 20mg of these active ingredients. As a dietary supplement, a recommended 1 Serving (1 Capsule) may be taken 3-4 times per day, preferably with a meal, or as advised by a heath care professional.

In addition to True Nutrition‘s Guggulsterone Capsules, True Nutrition offers a variety of other ingredients aimed at increasing weight loss potential:

It is our goal to help you meet your goals, and adding True Nutrition‘s Guggulsterone Capsules to your daily supplementation may be the key to your continued success! Ask us how guggulsterones can complement your healthy lifestyle today!

*DISCLAIMER: The above description is provided for information only and does not constitute medical advice. Please consult your physician or the appropriately licensed professional before engaging in a program of exercise or nutritional supplementation. No information in this site has been reviewed by the FDA. No product is intended to treat, diagnose, or cure any disease.

References:

1. Deng R, Yang D, Radke A, Yang J, Yan B. (2007). “The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism”. J Pharmacol Exp Ther. 320(3): p. 1153-62.
2. Szapary P, et al. (2003). “Guggulipid Ineffective for Lowering Cholesterol”. JAMA. 290(6): p. 765–772.
3. Sahni S, Hepfinger CA, Sauer KA. (2005). “Guggulipid Use in Hyperlipidemia”. Am J Health-Syst Pharm. 62(16): p. 1690–1692.
4. Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. (1988). “Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action”. Planta Med. 54(4): p. 271-7.
5. Panda S, Kar A. (1999). “Gugulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation”. Life Sci. 65(12): PL137-41.
6. Bhatt AD, et al. (1995). “Conceptual and methodologic challenges of assessing the short-term efficacy of Guggulu in obesity: data emergent from a naturalistic clinical trial”. J Postgrad Med. 41(1): p. 5-7.
7. Thappa DM, Dogra J. (1994). “Nodulocystic acne: oral gugulipid versus tetracycline”. J Dermatol. 21(10): p. 729-31.

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