is an amino acid (building block of protein) that also provides the nitrogen used to make nitric oxide (NO), once known as endothelial-derived relaxing factor. NO acts on the smooth muscle of the small blood vessels (e.g., in the capillary beds of skeletal muscle) to cause vasodilation and increase blood flow to tissue. (Nitroglycerin, a common treatment for poor coronary artery blood flow, works by producing NO.)
Oral arginine (e.g, 5g / day) normalizes NO levels in those with low NO production(1) and may therefore enhance blood flow during and after exercise. Additionally, by improving the general function of the vascular endothelium (inside of blood vessels), long-term use of arginine may be beneficial for individuals with high blood pressure of poor blood lipid profiles (high cholesterol)(2). Oral arginine may also be helpful, in the same way that viagra can be, for individuals with erectile dysfunction(1).
NO also promotes lipolysis (fat breakdown) per se(3), suggesting that arginine may help with the utilization of body fat stores during exercise or when dieting for fat loss. On the other hand, NO is also has pro-oxidant (free radical) effects suggesting caution with chronic use (see below). In years past, arginine has been touted as a growth hormone (GH) releaser. Although arginine infusion will elevate blood levels of GH, oral arginine does not seem to produce this response(4).
Arginine (~5g servings) might be used pre- or post-workout to optimize NO levels, blood flow and nutrient delivery to exercising or recovering muscle. It might be used as part of an exercise and dietary regimen designed for fat loss along with supplements such as Green Tea Extract, caffeine, and L-Tyrosine. Arginine could also be used to optimize nutrient delivery in a post-workout or weight gainer drink along Alpha Lipoic Acid, waxy maize and/or other carbohydrate source, and a high quality protein blend. Finally, in conjunction with a doctor’s advice, arginine might be considered along with Tribulus Terrestris as part of a complementary effort to treat erectile dysfunction.
While large amounts of supplemental arginine (e.g., 20g / day) may provide circulatory benefit, chronically elevating nitric oxide might also create a free-radical stress that would ideally be neutralized by the body, with diet and/or with dietary supplement intake, e.g., with anti-oxidants such as ascorbic acid (vitamin C) or Alpha Lipoic Acid.
As a dietary supplement, take 1 Serving (5,000mg) 1-2 times daily, or as prescribed by a healthcare professional.
Packaged in heat-sealed foil pouches.
If you are currently pregnant or nursing, consult a physician prior to use. Keep out of the reach of children.
This product is free from all forms of shell fish, tree nuts, yeast, gluten, salt, preservatives, lactose, and soy. This product is manufactured in a facility that handles soy, gluten, and milk products. Products ordered using Premium Flavor Systems will contain artificial flavoring and sweeteners. This product is manufactured in a facility that handles milk, soy, egg, peanut, nut, tree, fish, crustaceans/shellfish, and wheat products.
Use the table below to approximate the gram equivalent weight for a given level measuring spoon (US Standard). Please note that accurate dosing should only be done with a recommended calibrated scale.
|Measuring Spoon (level)
DISCLAIMER: The above description is provided for information only and does not constitute medical advice. Please consult your physician or the appropriately licensed professional before engaging in a program of exercise or nutritional supplementation. No information in this site has been reviewed by the FDA. No product is intended to treat, diagnose, or cure any disease.
1. Chen, J., et al., Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU Int, 1999. 83(3): p. 269-73. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10233492
2. Clarkson, P., et al., Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest, 1996. 97(8): p. 1989-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8621785
3. Jobgen, W.S., et al., Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem, 2006. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16524713
4. Chromiak, J.A. and J. Antonio, Use of amino acids as growth hormone-releasing agents by athletes. Nutrition, 2002. 18(7-8): p. 657-61. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12093449