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DIM (Diindolylmethane)100mg Capsules (120 Caps)


DIM (Diindolylmethane)100mg Capsules (120 Caps)

DIM (Diindolylmethane) 100mg Capsules (120 Capsules)

(SKU:9858)
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A powerful estrogen-blocker!*
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DIM is the primary metabolite of Indole3 Carbinol(I3C), a compound found in cruciferous vegetables (like broccoli, cauliflower, radishes and turnips)(6). It has been widely studied for its anti-carcinogenic effects(17), in particular in protecting against or halting the progression of estrogen and androgen-sensitive cancers like breast and prostate cancer. DIM is also used to treat respiratory papillomas(18) and has an anti-proliferative effect onthyroid goiter cells, contrary to the belief that DIM is goitrogenic(15).

DIM demonstrates an anti-androgenic effect in prostate cancer by inhibiting effects of dihydrotestosterone (DHT)(9), likely by directly competing for DHT at the androgen receptor(3, 9). Like its parent compound I3C, DIM has diverse effects on estrogen metabolism, favoring the formation of anti-estrogenic metabolites at the expense of estrogenic ones(7, 11). Interestingly, DIM in and of itself is actually an agonist (activator) of the human estrogen receptor (3), which may explain the notion that DIM “balances” estrogen’s effects. DIM may be superior as a supplement to I3C for those minimizing estrogenic effects, because, unlike I3C, DIM does not affect metabolism of the anti-breast cancer drug (estrogen receptor antagonist) tamoxifen or increase its toxic metabolites(11). Additionally, at least in rats, DIM does not disrupt the hypothalamic pituitary ovarian axis (involved in estrogen synthesis) in the manner that I3C does(5).

The effects of DIM are largely attributed to its diverse effects on the cytochromes p450 (CYP)(8,10, 14), a large hepatic enzyme group involved in metabolism of a great many drugs and toxins by the liver(13). Because of this, please consult your healthcare professional about possible interactions DIM may have with any medications you are taking.

Benefits and Risks

DIM may be helpful in minimizing possible cancer risks of hormone replacement (both estrogen and testosterone based) by affecting the actions of these hormones on the breast and prostate, as well as confer anti-tumor effects on the thyroid, lung and colon(2). On the other hand, it should be noted that excessively high doses seem to be associated with toxicity and pro-tumor effects in animal research(12). However, when the equivalent of a human dose of ~600mg / day (for a 220lb bodybuilder; 2-3 times the typically suggested dose), was given to rats for 32 days, neither body weight, blood chemistry nor histology of liver, kidney or bone(4) were affected, suggesting minimal adverse consequences, at least for rodents, at this dose.

In one study of healthy adults(12), increasing the dose of DIM from 200mg to 300mg did not further elevate DIM blood levels. Additionally, side effects below 300mg/day were not found to be dose-dependent. As reviewed by Reed et al.(12), compared to an equivalent dose of I3C, oral supplementation with DIM produces 2-3 times higher DIM, and is well tolerated in the 200-400mg/ day range, when split over two doses.

Supplement Use

The above suggests that a daily dose of 100-200mg, spread over two doses, DIM could be used to protect against potential adverse effects of supplements that may elevate blood hormone levels, such as D-Aspartic Acid, Tribulus Terrestris or MG’s Super Test Booster. Patients concerned with possible elevation of cancer risk associated with hormone replacement therapy (estrogen(16) or testosterone(1)) should check with their respective physicians to see if DIM may be a useful adjunctive prophlactic against tumorigenesis. Naturally, the anti-cancer benefits of DIM make it an attractive addition to a supplement regime geared toward health and longevity, especially in the face of familial history of cancer. PLEASE CONSULT YOUR HEALTHCARE PROVIDER before taking DIM if you are current taking any prescribed or over-the-counter medications, as DIM may affect drug metabolism and necessitate dosage adjustment.

Ingredients

Active Ingredients

DIM (Diindolylmethane).

Inactive Ingredients

Magnesium Stearate (Vegetable), Capsule (Vegetable Cellulose).

General Warnings

If you are currently pregnant or nursing, consult a physician prior to use. Keep out of the reach of children.

Allergen Warnings

Although this product may not contain one or all of the following, this product is manufactured in a facility that handles milk, soy, egg, peanut, nut, tree, fish, crustaceans/shellfish, and wheat products.

DISCLAIMER: The above description is provided for information only and does not constitute medical advice.  Please consult your physician or the appropriately licensed professional before engaging in a program of exercise or nutritional supplementation.  No information in this site has been reviewed by the FDA.  No product is intended to treat, diagnose, or cure any disease.

References

1. BassilN, and Morley JE. Late-life onset hypogonadism: a review. ClinGeriatr Med 26: 197-222, 2010.

2. BonnesenC, Eggleston IM, and Hayes JD. Dietary indoles and isothiocyanatesthat are generated from cruciferous vegetables can both stimulateapoptosis and confer protection against DNA damage in human coloncell lines. Cancer Res 61: 6120-6130, 2001.

3. BoveeTF, Schoonen WG, Hamers AR, Bento MJ, and Peijnenburg AA. Screeningof synthetic and plant-derived compounds for (anti)estrogenic and(anti)androgenic activities. Anal Bioanal Chem 390: 1111-1119, 2008.

4. ElackattuAP, Feng L, and Wang Z. A controlled safety study of diindolylmethanein the immature rat model. Laryngoscope 119: 1803-1808, 2009.

5. Gao X,Petroff BK, Oluola O, Georg G, Terranova PF, and Rozman KK. Endocrinedisruption by indole-3-carbinol and tamoxifen: blockage of ovulation.Toxicol Appl Pharmacol 183: 179-188, 2002.

6. HigdonJV, Delage B, Williams DE, and Dashwood RH. Cruciferous vegetablesand human cancer risk: epidemiologic evidence and mechanistic basis.Pharmacol Res 55: 224-236, 2007.

7. HornTL, Reichert MA, Bliss RL, and Malejka-Giganti D. Modulations of P450mRNA in liver and mammary gland and P450 activities and metabolism ofestrogen in liver by treatment of rats with indole-3-carbinol.Biochem Pharmacol 64: 393-404, 2002.

8. LakeBG, Tredger JM, Renwick AB, Barton PT, and Price RJ.3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut humanliver slices. Xenobiotica 28: 803-811, 1998.

9. Le HT,Schaldach CM, Firestone GL, and Bjeldanes LF. Plant-derived3,3'-Diindolylmethane is a strong androgen antagonist in humanprostate cancer cells. The Journal of biological chemistry 278:21136-21145, 2003.

10. ParkinDR, Lu Y, Bliss RL, and Malejka-Giganti D. Inhibitory effects of adietary phytochemical 3,3'-diindolylmethane on thephenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzedreactions in female rats. Food Chem Toxicol 46: 2451-2458, 2008.

11. ParkinDR, and Malejka-Giganti D. Differences in the hepatic P450-dependentmetabolism of estrogen and tamoxifen in response to treatment of ratswith 3,3'-diindolylmethane and its parent compound indole-3-carbinol.Cancer Detect Prev 28: 72-79, 2004.

12. ReedGA, Sunega JM, Sullivan DK, Gray JC, Mayo MS, Crowell JA, and HurwitzA. Single-dose pharmacokinetics and tolerability ofabsorption-enhanced 3,3'-diindolylmethane in healthy subjects. CancerEpidemiol Biomarkers Prev 17: 2619-2624, 2008.

13. RendicS. Summary of information on human CYP enzymes: human P450 metabolismdata. Drug Metab Rev 34: 83-448, 2002.

14. StresserDM, Bjeldanes LF, Bailey GS, and Williams DE. The anticarcinogen3,3'-diindolylmethane is an inhibitor of cytochrome P-450. J BiochemToxicol 10: 191-201, 1995.

15. TadiK, Chang Y, Ashok BT, Chen Y, Moscatello A, Schaefer SD, Schantz SP,Policastro AJ, Geliebter J, and Tiwari RK. 3,3'-Diindolylmethane, acruciferous vegetable derived synthetic anti-proliferative compoundin thyroid disease. Biochemical and biophysical researchcommunications 337: 1019-1025, 2005.

16. TaylorHS, and Manson JE. Update in hormone therapy use in menopause. TheJournal of clinical endocrinology and metabolism 96: 255-264, 2011.

17. WengJR, Tsai CH, Kulp SK, and Chen CS. Indole-3-carbinol as achemopreventive and anti-cancer agent. Cancer letters 262: 153-163,2008.

18. Wiatrak BJ. Overview of recurrentrespiratory papillomatosis. Curr Opin Otolaryngol Head Neck Surg 11:433-441, 2003.


Serving Size 1 (1ca)
Servings Per Container 120
Amount Per Serving
% Daily Value*
Diindolylmethane 100mg
**
** Percent Daily Values not established.

The above statement has not been evaluated by the FDA. This product is not intended to diagnose or treat any disease.

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